William Hudson (3 April 1664-17 December 1742) was Mayor of Philadelphia from 5 October 1725 to 4 October 1726, succeeding Isaac Norris and preceding Charles Read. Born in York, England, he settled in Pennsylvania in 1684 and worked as a merchant. He served on the common council, in the provincial assembly, as an alderman, as a city judge, and as a social reformer, advocating for the lessening of prisoners' suffering and Quaker influence in colonial politics. He was one of the last Quaker mayors of Philadelphia.