The Susquehannock, also known as the Conestoga, were a Native American people that inhabited the lands along the Susquehanna River in New York, Maryland, and Pennsylvania. In 1600, the tribe had a population of 7,000 people, and the tribe became a regional power due to its alliances with Sweden and the United Provinces. The tribe fought off invasions by the Iroquois, a tribe allied to England, and it defeated Maryland in a war that lasted from 1642 to 1650. However, the tribe declined in power during the 1670s due to the smallpox epidemic, and the Iroquois overwhelmed them by 1678.