Sam Greene (died April 1865) was a member of the US House of Representatives (R-IN) during the 1850s and 1860s. An ardent abolitionist and an associate of Gerrit Smith, he was smitten with the socialite Virgilia Hazard and, although she repeatedly rejected his advances due to his married status, he persuaded her to have an affair with him in exchange for his help with making her a nurse during the American Civil War. In 1864, he sheltered Virgilia after she was accused of murdering a Confederate prisoner of war and attempting to kill her elderly supervisor, but, as the Republicans planned to make Greene their US Senate candidate in Indiana in 1865, Greene decided to call off his relationship with Virgilia to save his political career. Virgilia, who had become impatient over Greene's failure to remove the assault charge against her, and who learned that Greene had covered up the withdrawal of the murder charge against her so that he could force her to sleep with him, angrily shot Greene dead before he could leave her home.

