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The Pyrolusite Laboratory Dos raid occurred in 2019 when American special forces raided a pyrolusite laboratory used by the Santa Blanca Cartel.

Mined in Villa Verde Province, pyrolusite was processed in labs acrorss the province for use in cocaine production. To cut off the flow of pyrolusite to the cartel, Major Anthony Perryman and his Ghost Recon team raided Pyrolusite Laboratory Dos, launching a nighttime raid and killing several cartel sicarios. Perryman destroyed the laboratory's generator with gunfire, shutting down the lab's operations.

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