The Guamuchil shootout occurred in January 2016 when Los Mazatlecos boss Fausto Isidro Meza Flores attempted to murder the Sinaloa Cartel boss El Chapo in Guamuchil, Sinaloa. El Chapo was, at the time, subjected to a major manhunt by Secretary of State Conrado Higuera Sol, and he repeatedly evaded capture before being smuggled into Guamuchil by corrupt Mexican Federal Police. El Chapo, who had been wounded in the leg during a previous shootout with the law, was hidden in the trunk of a police car which was taking a pre-paid, beaten-up man (passed off as a drunken brawler) to jail in Guamuchil, and the police car carrying El Chapo claimed that it was taking the officer's wounded aunt to the hospital to treat a leg wound. Isidro, El Chapo's archenemy, learned of the correlation after reading a newspaper article of how El Chapo had alos been wounded in the leg, and he received confirmation about El Chapo's whereabouts from a kidnapped and interrogated policeman. As El Chapo was driven around town in Orso Ivan Gastelum Cruz's pickup truck, several truckloads of Los Mazatlecos hitmen (including Isidro himself) ambushed the Sinaloa Cartel convoy. El Chapo was hurried from the trunk of "El Cholo Ivan"'s pickup truck into a police truck, which helped him escape; however, around five Sinaloa gunmen and one corrupt policeman were killed in the shootout. Ultimately, El Chapo decided to relocate to where he would be least suspected to stay: Los Mochis, Isidro's turf. Even Isidro doubted this, searching the mountains for El Chapo. However, Secretary of State Higuera Sol correctly predicted that El Chapo would move to Los Mochis, where he and Gastelum Cruz were arrested in an 8 January 2016 raid.
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