The Advanced Drug Development Center (ADDC) was a medical research facility that existed in in Tokyo, Japan from 2002 to 2019. The ADDC was formed in 2002 by LDP lawmaker Kaoru Ichinose as part of the Ministry of Health, Labour and Welfare's Medical Institute, and it was allegedly created with the sole purpose of providing politicians with cozy retirement jobs. The ADDC nearly closed down in the late 2000s as Japan's aging population crisis waned and the Great Recession set in, and the real estate developer Shigeru Kajihira, who was interested in redeveloping its land, employed the help of ADDC vice-director Toru Hashiki to sabotage the center (through selling its projects to rival companies) into closure. However, Yoji Shono's development of the AD-9 Alzheimer's treatment in the 2010s led to the government giving the ADDC a blank check to continue their work. Hashiki was murdered in 2018 on the orders of Vice-Minister for Health Ichinose, putting an end to his plotting to close the ADDC. However, Shono's secret clinical trials of AD-9 from 2015 to 2018 resulted in several deaths, forcing Shono to hire the policeman Mitsuru Kuroiwa to gouge out the eyes of his drug's victims to hide the blue pigmentation that served as a telltale sign of AD-9's lethal toxicity. From December 2018 to January 2019, the private detective Takayuki Yagami uncovered the AD-9 conspiracy, resulting in Ichinose's arrest, Kuroiwa and Shono's deaths, and the ADDC's closure.
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