The 52nd North Carolina Infantry Regiment was a North Carolinian infantry regiment of the Confederate States Army that was active from April 1862 to April 1865 during the American Civil War. Raised in Cabarrus, Randolph, Gates, Chowan, Stokes, Richmond, Wilkes, Lincoln, Stanly, and Forsyth counties, the regiment fought with the Army of Northern Virginia from the Battle of Gettysburg to the Appomattox campaign.